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This is a series of the latest published research on Alpha-1 Antitrypsin Deficiency. It is updated monthly, based on a search. Previous months’ listings are archived in the left sidebar of this page.

July 2019 Publications

Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.
Riley BT, Hoke DE, McGowan S, Buckle AM.
Acta Crystallogr F Struct Biol Commun. 2019 Aug 1;75(Pt 8):543-546. doi: 10.1107/S2053230X19009610. Epub 2019 Jul 16.
PMID: 31397325 [PubMed – in process]

Severe bilateral descemetoceles in Alpha-1 antitrypsin deficiency.
Ma J, Baqai J.
Am J Ophthalmol Case Rep. 2019 Jul 10;15:100513. doi: 10.1016/j.ajoc.2019.100513. eCollection 2019 Sep.
PMID: 31360795 [PubMed] Free PMC Article

Serine protease inhibitors and activators from Dalbergia tonkinensis species.
Son NT, Suenaga M, Matsunaga Y, Van Chinh L, Kubo M, Harada K, Cuong NM, Fukuyama Y.
J Nat Med. 2019 Jul 27. doi: 10.1007/s11418-019-01347-y. [Epub ahead of print]
PMID: 31352545 [PubMed – as supplied by publisher]

Alpha 1-antitrypsin for treating ventilator-associated lung injury in acute respiratory distress syndrome rats.
Wang X, Gong J, Zhu J, Jin Z, Gao W.
Exp Lung Res. 2019 Sep;45(7):209-219. doi: 10.1080/01902148.2019.1642968. Epub 2019 Jul 26.
PMID: 31347410 [PubMed – in process]

Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury.
Juschten J, Ingelse SA, Maas MAW, Girbes ARJ, Juffermans NP, Schultz MJ, Tuinman PR.
Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):36. doi: 10.1186/s40635-019-0240-7.
PMID: 31346884 [PubMed] Free PMC Article

What Do Alpha-1 Antitrypsin Levels Tell Us About Chronic Inflammation in COPD?
Ellis P, Turner A.
Arch Bronconeumol. 2019 Jul 21. pii: S0300-2896(19)30285-6. doi: 10.1016/j.arbres.2019.06.010. [Epub ahead of print] English, Spanish. No abstract available.
PMID: 31340890 [PubMed – as supplied by publisher] Free Article

Characterization of active anticoagulant fraction and a fibrin(ogen)olytic serine protease from leaves of Clerodendrum colebrookianum, a traditional ethno-medicinal plant used to reduce hypertension.
Gogoi D, Ramani S, Bhartari S, Chattopadhyay P, Mukherjee AK.
J Ethnopharmacol. 2019 Oct 28;243:112099. doi: 10.1016/j.jep.2019.112099. Epub 2019 Jul 18.
PMID: 31326559 [PubMed – in process]

Vascular Alpha-1 Adrenergic Sensitivity is Enhanced in Chronic Kidney Disease.
Sprick JD, Morison DL, Stein CM, Li Y, Paranjape SY, Fonkoue IT, DaCosta DR, Park J.
Am J Physiol Regul Integr Comp Physiol. 2019 Jul 17. doi: 10.1152/ajpregu.00090.2019. [Epub ahead of print]
PMID: 31314543 [PubMed – as supplied by publisher]

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.
Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N.
Sci Rep. 2019 Jul 16;9(1):10310. doi: 10.1038/s41598-019-46639-1.
PMID: 31311979 [PubMed – in process] Free PMC Article

Protein modeling to assess the pathogenicity of rare variants of SERPINA1 in patients suspected of having Alpha 1 Antitrypsin Deficiency.
Kueppers F, Andrake MD, Xu Q, Dunbrack RL Jr, Kim J, Sanders CL.
BMC Med Genet. 2019 Jul 15;20(1):125. doi: 10.1186/s12881-019-0852-5.
PMID: 31307431 [PubMed – in process] Free PMC Article

Metacaspase-3 of Plasmodium falciparum: An atypical trypsin-like serine protease.
Kumar B, Verma S, Kashif M, Sharma R, Atul, Dixit R, Singh AP, Pande V, Saxena AK, Abid M, Pandey KC.
Int J Biol Macromol. 2019 Jul 10;138:309-320. doi: 10.1016/j.ijbiomac.2019.07.067. [Epub ahead of print]
PMID: 31301397 [PubMed – as supplied by publisher]

SERPINA1 gene polymorphisms in a population-based ALSPAC cohort.
DeLuca DS, Poluzioroviene E, Taminskiene V, Wrenger S, Utkus A, Valiulis A, Alasevičius T, Henderson J, Bush A, Welte T, Janciauskiene S, Valiulis A.
Pediatr Pulmonol. 2019 Jul 12. doi: 10.1002/ppul.24422. [Epub ahead of print]
PMID: 31298815 [PubMed – as supplied by publisher]

Down-regulation of tissue levels of serine protease inhibitor (vaspin) in psoriasis vulgaris patients: a possible mechanism of narrowband ultraviolet B radiation.
Sayed KS, Said ER, Mohammed FN, Algorhary M, Rashed LA.
Arch Dermatol Res. 2019 Jul 10. doi: 10.1007/s00403-019-01947-4. [Epub ahead of print]
PMID: 31292731 [PubMed – as supplied by publisher]

para-Sulphonato-calix[n]arene capped silver nanoparticles challenge the catalytic efficiency and the stability of a novel human gut serine protease inhibitor.
Akermi N, Mkaouar H, Kriaa A, Jablaoui A, Soussou S, Gargouri A, Coleman AW, Perret F, Maguin E, Rhimi M.
Chem Commun (Camb). 2019 Aug 7;55(61):8935-8938. doi: 10.1039/c9cc03183a. Epub 2019 Jul 9.
PMID: 31286126 [PubMed – indexed for MEDLINE]

Light scattering determination of the stoichiometry for protease-potato serine protease inhibitor complexes.
Billinger E, Zuo S, Lundmark K, Johansson G.
Anal Biochem. 2019 Oct 1;582:113357. doi: 10.1016/j.ab.2019.113357. Epub 2019 Jul 2.
PMID: 31276650 [PubMed – in process]

Alpha-1 Antitrypsin Replacement in Patients With COPD.
Wells AD, Woods A, Hilleman DE, Malesker MA.
P T. 2019 Jul;44(7):412-415.
PMID: 31258312 [PubMed] Free PMC Article

Alpha-1 Antitrypsin Deficiency: A Predisposing Factor for the Development of Pulmonary Langerhans Cell Histiocytosis.
Ellis PR, Campbell EJ, Turner AM, Stockley RA.
Chronic Obstr Pulm Dis. 2019 Jul 24;6(3):206-209. doi: 10.15326/jcopdf.6.3.2019.0129. No abstract available.
PMID: 31247686 [PubMed] Free Article

The reaction mechanism of Zika virus NS2B/NS3 serine protease inhibition by dipeptidyl aldehyde: a QM/MM study.
Nutho B, Mulholland AJ, Rungrotmongkol T.
Phys Chem Chem Phys. 2019 Jul 10;21(27):14945-14956. doi: 10.1039/c9cp02377a.
PMID: 31236554 [PubMed – indexed for MEDLINE]

The α-1,6-mannosyltransferase VdOCH1 plays a major role in microsclerotium formation and virulence in the soil-borne pathogen Verticillium dahliae.
Zhang J, Zhang Y, Yang J, Kang L, EloRM AM, Zhou H, Zhao J.
Fungal Biol. 2019 Jul;123(7):539-546. doi: 10.1016/j.funbio.2019.05.007. Epub 2019 May 18.
PMID: 31196523 [PubMed – in process]

Proinflammatory Effects of Cardiotonic Steroids Mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src Complex in Renal Epithelial Cells and Immune Cells.
Khalaf FK, Dube P, Kleinhenz AL, Malhotra D, Gohara A, Drummond CA, Tian J, Haller ST, Xie Z, Kennedy DJ.
Hypertension. 2019 Jul;74(1):73-82. doi: 10.1161/HYPERTENSIONAHA.118.12605. Epub 2019 May 28.
PMID: 31132948 [PubMed – in process]

The prognostic potential of alpha-1 type I collagen expression in papillary thyroid cancer.
Huang C, Yang X, Han L, Fan Z, Liu B, Zhang C, Lu T.
Biochem Biophys Res Commun. 2019 Jul 12;515(1):125-132. doi: 10.1016/j.bbrc.2019.04.119. Epub 2019 May 22.
PMID: 31128912 [PubMed – in process]

Targeting the site encoded by SERPINA1*E342K for treating alpha-1 antitrypsin deficiency-associated liver diseases.
Zhang X, Pham K, Li D, Schutte RJ, Brantly M, Liu C, Ostrov DA.
FEBS Lett. 2019 Jul;593(14):1849-1862. doi: 10.1002/1873-3468.13452. Epub 2019 Jun 6.
PMID: 31116417 [PubMed – in process]

In vitro silencing of a serine protease inhibitor suppresses Trichinella spiralis invasion, development, and fecundity.
Yang F, Yang DQ, Song YY, Guo KX, Li YL, Long SR, Jiang P, Cui J, Wang ZQ.
Parasitol Res. 2019 Jul;118(7):2247-2255. doi: 10.1007/s00436-019-06344-4. Epub 2019 May 12.
PMID: 31081529 [PubMed – in process]

Liver Disease Due to Alpha-1 Antitrypsin Deficiency: Are We Surprised That It Is More Complex Than We Thought?
Di Bisceglie AM, Teckman J.
Hepatology. 2019 Jul;70(1):5-7. doi: 10.1002/hep.30694. Epub 2019 May 31. No abstract available.
PMID: 31058323 [PubMed – in process]

GDNF family receptor alpha 1 is a reliable marker of undifferentiated germ cells in bulls.
Kim YH, Choi YR, Kim BJ, Jung SE, Kim SM, Jin JH, Yun MH, Kim SU, Kim YH, Hwang S, Pang MG, Ryu BY.
Theriogenology. 2019 Jul 1;132:172-181. doi: 10.1016/j.theriogenology.2019.04.016. Epub 2019 Apr 16.
PMID: 31029848 [PubMed – in process]

Immunoreactivity changes of human serum albumin and alpha-1-microglobulin induced by their interaction with dendrimers.
Serchenya T, Shcharbin D, Shyrochyna I, Sviridov O, Terekhova M, Dzmitruk V, Abashkin V, Apartsin E, Mignani S, Majoral JP, Ionov M, Bryszewska M.
Colloids Surf B Biointerfaces. 2019 Jul 1;179:226-232. doi: 10.1016/j.colsurfb.2019.03.065. Epub 2019 Apr 4.
PMID: 30974260 [PubMed – in process]

The Plasmodium berghei serine protease PbSUB1 plays an important role in male gamete egress.
Pace T, Grasso F, Camarda G, Suarez C, Blackman MJ, Ponzi M, Olivieri A.
Cell Microbiol. 2019 Jul;21(7):e13028. doi: 10.1111/cmi.13028. Epub 2019 Apr 29.
PMID: 30941868 [PubMed – in process] Free Article

How many protein molecules are secreted by single Helicobacter pylori cells: Quantification of serine protease HtrA.
Neddermann M, Backert S.
Cell Microbiol. 2019 Jul;21(7):e13022. doi: 10.1111/cmi.13022. Epub 2019 Mar 19.
PMID: 30822363 [PubMed – in process]

Tissue and Exosomal Serine Protease Inhibitors Are Significantly Overexpressed in Chronic Rhinosinusitis With Nasal Polyps.
Mueller SK, Nocera AL, Dillon ST, Libermann TA, Wendler O, Bleier BS.
Am J Rhinol Allergy. 2019 Jul;33(4):359-368. doi: 10.1177/1945892419831108. Epub 2019 Feb 27. No abstract available.
PMID: 30810048 [PubMed – in process]

Alpha-1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity.
Wang L, Marek GW 3rd, Hlady RA, Wagner RT, Zhao X, Clark VC, Fan AX, Liu C, Brantly M, Robertson KD.
Hepatology. 2019 Jul;70(1):51-66. doi: 10.1002/hep.30526. Epub 2019 Mar 20.
PMID: 30681738 [PubMed – in process]

Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer’s Disease Brain.
Darreh-Shori T, Rezaeianyazdi S, Lana E, Mitra S, Gellerbring A, Karami A, Bogdanovic N, Lithner CU, Winblad B, Behbahani H.
Mol Neurobiol. 2019 Jul;56(7):4601-4619. doi: 10.1007/s12035-018-1383-3. Epub 2018 Oct 25.
PMID: 30361890 [PubMed – in process] Free PMC Article

Alpha-1 Adrenergic Receptor Agonist Phenylephrine Inhibits Sepsis-Induced Cardiomyocyte Apoptosis and Cardiac Dysfunction via Activating ERK1/2 Signal Pathway.
Li H, Xing Y, Yang D, Tang X, Lu D, Wang H.
Shock. 2019 Jul;52(1):122-133. doi: 10.1097/SHK.0000000000001205. PMID: 29889817 [PubMed – in process]

  • alpha 1-Antitrypsin
  • alpha one antitrypsin
  • alpha 1 antitrypsine
  • alpha1-AT deficiency
  • alpha-1-AT
  • alpha 1 antiproteinase
  • alpha 1 antiprotease
  • alpha 1 protease
  • alpha 1 proteinase
  • familial emphysema
  • genetic emphysema
  • AATD
  • A1AT
  • hA1AT
  • A1-AT
  • A1P1
  • Prolastin
  • Aralast
  • Zemaira
  • Glassia


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