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DNA & Tissue Bank
Petry Dishes Alpha-1 DNA

The mission of the Alpha-1 Foundation DNA and Tissue Bank at the University of Florida is to provide researchers with DNA, plasma and tissue from patients with Alpha-1 Antitrypsin Deficiency to promote discovery and new therapies relevant to people with Alpha-1.

The bank, established in 2002, has more than 2,500 members enrolled and is available for researchers to request medical information (the names of donors are not revealed) and samples for research projects. Mark Brantly, MD, is the principal investigator and supervisor of the DNA and Tissue Bank.

Most enrolled subjects have provided medical information and blood samples. In addition, pulmonary function and liver enzyme testing results are a part of the bank’s data set.

High-quality genomic DNA, plasma and limited amounts of lung and liver tissue, paired with an extensive clinical database, are available for researchers interested in Alpha-1 Antitrypsin Deficiency. The collection includes spouses and family members as controls, along with a large cohort of alpha-1 antitrypsin deficient individuals maintained with regulatory control UF IRB 201500842 (formerly 659-2002), operating under an NIH confidentiality agreement. The collection includes 2393 DNA and plasma samples, specifically 805 PI ZZ, 221 Rare/null, 87 SZ, 3 SS, 478 MZ, 109 MS, and 689 MM samples.

In addition, the collection includes formalin-fixed lung tissue from 22 people, including 13 ZZ, 5 MM, 1 MF, 2 MZ, and 1 MS, plus 19 liver samples, including 16 ZZ, 2 MZ and 1 MS. The number of fresh frozen samples available for study is limited.

 Researchers wishing to obtain samples can go to the Alpha-1 UF website and fill out an inquiry form. Someone from the team will contact you and go over the request process.

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