The mission of the Alpha-1 Foundation DNA and Tissue Bank at the University of Florida is to provide researchers with DNA, plasma and tissue from patients with Alpha-1 Antitrypsin Deficiency to promote discovery and new therapies relevant to people with Alpha-1.
The bank, established in 2002, has more than 2,500 members enrolled and is available for researchers to request medical information (the names of donors are not revealed) and samples for research projects. Mark Brantly, MD, is the principal investigator and supervisor of the DNA and Tissue Bank.
Most enrolled subjects have provided medical information and blood samples. In addition, pulmonary function and liver enzyme testing results are a part of the bank’s data set.
In addition, the collection includes formalin-fixed lung tissue from 22 people, including 13 ZZ, 5 MM, 1 MF, 2 MZ, and 1 MS, plus 19 liver samples, including 16 ZZ, 2 MZ and 1 MS. The number of fresh frozen samples available for study is limited.
Researchers wishing to obtain samples of DNA and tissue should contact David Fernandez, at dfernandez@alpha1.org or at (877) 228-7321 ext. 242.
