Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype  | Vertex Pharmaceuticals Incorporated | VX-864 & Placebo | Click Here for Locations | | 18-35,35-65,65+ | | |
| Liver Disease in Patients with Alpha-1 Antitrypsin Deficiency | RWTH Aachen University | Observational | Click Here for Locations | M,F | 0-18,18-35,35-65,65+ | Liver | MS |
| Phase 1 study to assess the safety, PK and PD of INBRX-101 in adults with Alpha-1 (rhAAT-Fc) | Inhibrx, Inc. | INBRX-101/rhAAT-Fc | Click Here for Locations | M,F | 18-35,35-65,65+ | | MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Effects of different exercise training modalities in Alpha-1 Antitrypsin Deficiency | Schön Klinik Berchtesgadener Land | Observational | Click Here for Locations | M,F | 35-65,65+ | | ZZ |
| A Study of DCR-A1AT in Healthy Adult Volunteers and Patients With A1ATD-Associated Liver Disease | Dicerna Pharmaceuticals, Inc. | DCR-A1AT & placebo | Click Here for Locations | ,M,F | 18-35,35-65,65+ | Liver | ZZ |
| Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency | University of Alabama at Birmingham | Alvelestat & Placebo | Click Here for Locations
| M,F | 18-35,35-65,65+ | | SZ,ZZ |
| Alpha-1 Research Registry | Alpha-1 Foundation | | Click Here for Locations | M,F | 0-18,18-35,35-65,65+ | Liver,Lung | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis | Medical University of South Carolina | | Click Here for Locations | ,M,F | 18-35,35-65,65+ | | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| COPD Exacerbation Blood and Urine Biomarkers Study | Columbia University Medical Center | | Click Here for Locations | M,F | 35-65,65+ | | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs | University of Florida | Albuterol inhaler | Click Here for Locations | M,F | 18-35,35-65,65+ | Lung | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease | McMaster University | Hyperpolarized 129Xe & MRI | Click Here for Locations | M,F | 18-35,35-65,65+ | Lung | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Assessment of Changes in a Novel Histological Activity Scale in Response to ARO-AAT | Arrowhead Pharmaceuticals | ARO-AAT Injection | Click Here for Locations | M,F | 18-35,35-65,65+ | | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Safety, Tolerability and Effect on Liver Histologic Parameters of ARO-AAT | Arrowhead Pharmaceuticals | ARO-AAT Injection & Placebo | Click Here for Locations | M,F | 18-35,35-65,65+ | Liver | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. | Mereo BioPharma | Alvelestat oral tablet & Placebo | Click Here for Locations | M,F | 18-35,35-65,65+ | | Z,M,S,ZZ |
| Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype | Vertex Pharmaceuticals Incorporated | Vx-814 & Placebo | Click Here for Locations | M,F | 18-35,35-65,65+ | | ZZ |
| The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft‑Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant | CSL Behring | Alpha-1 Proteinase inhibitor & Placebo | Click Here for Locations | M,F | | | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC) | Arbor Research Collaborative for Health | | Click Here for Locations | M,F | 0-18,18-35 | Liver | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD) | Grifols Therapeutics LLC | Prolastin-C & Placebo | Click Here for Locations | M,F | 18-35,35-65,65+ | | Z,S,SZ,ZZ |
| Alpha-1 Antitrypsin Deficiency Adult liver study | St. Louis University | Liver Biopsy | Click Here for Locations | M,F | 0-18,18-35,35-65,65+ | Liver | ZZ |
| Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone | CSL Behring | Alpha-1 proteinase inhibitor & Placebo | Click Here for Locations | M,F | 18-35,35-65,65+ | | Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Earco Registry. History of Patients with Alpha-1 Antitrypsin | Hospital Universitari Vall d'Hebron Research Institute | None | Click Here for Locations | M,F | 0-18,18-35,35-65,65+ | | SZ,ZZ |
| Evaluate Efficacy and Safety of "Kamada-AAT for inhalation" in Patients with AATD | Kamada, Ltd. | Placebos | Click Here for Locations | M,F | 18-35,35-65 | | ZZ |
