Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype Vertex Pharmaceuticals Incorporated VX-864 & Placebo Click Here for Locations 18-35,35-65,65+ Liver Disease in Patients with Alpha-1 Antitrypsin Deficiency RWTH Aachen University Observational Click Here for Locations M,F 0-18,18-35,35-65,65+ Liver MS Phase 1 study to assess the safety, PK and PD of INBRX-101 in adults with Alpha-1 (rhAAT-Fc) Inhibrx, Inc. INBRX-101/rhAAT-Fc Click Here for Locations M,F 18-35,35-65,65+ MS,MZ,MF,SS,SZ,ZZ,FZ,FF Effects of different exercise training modalities in Alpha-1 Antitrypsin Deficiency Schön Klinik Berchtesgadener Land Observational Click Here for Locations M,F 35-65,65+ ZZ A Study of DCR-A1AT in Healthy Adult Volunteers and Patients With A1ATD-Associated Liver Disease Dicerna Pharmaceuticals, Inc. DCR-A1AT & placebo Click Here for Locations ,M,F 18-35,35-65,65+ Liver ZZ Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency University of Alabama at Birmingham Alvelestat & Placebo Click Here for Locations M,F 18-35,35-65,65+ SZ,ZZ Alpha-1 Research Registry Alpha-1 Foundation Click Here for Locations M,F 0-18,18-35,35-65,65+ Liver,Lung Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis Medical University of South Carolina Click Here for Locations ,M,F 18-35,35-65,65+ Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF COPD Exacerbation Blood and Urine Biomarkers Study Columbia University Medical Center Click Here for Locations M,F 35-65,65+ Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs University of Florida Albuterol inhaler Click Here for Locations M,F 18-35,35-65,65+ Lung Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease McMaster University Hyperpolarized 129Xe & MRI Click Here for Locations M,F 18-35,35-65,65+ Lung Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF Assessment of Changes in a Novel Histological Activity Scale in Response to ARO-AAT Arrowhead Pharmaceuticals ARO-AAT Injection Click Here for Locations M,F 18-35,35-65,65+ Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF Safety, Tolerability and Effect on Liver Histologic Parameters of ARO-AAT Arrowhead Pharmaceuticals ARO-AAT Injection & Placebo Click Here for Locations M,F 18-35,35-65,65+ Liver Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. Mereo BioPharma Alvelestat oral tablet & Placebo Click Here for Locations M,F 18-35,35-65,65+ Z,M,S,ZZ Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype Vertex Pharmaceuticals Incorporated Vx-814 & Placebo Click Here for Locations M,F 18-35,35-65,65+ ZZ The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft‑Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant CSL Behring Alpha-1 Proteinase inhibitor & Placebo Click Here for Locations M,F Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC) Arbor Research Collaborative for Health Click Here for Locations M,F 0-18,18-35 Liver Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD) Grifols Therapeutics LLC Prolastin-C & Placebo Click Here for Locations M,F 18-35,35-65,65+ Z,S,SZ,ZZ Alpha-1 Antitrypsin Deficiency Adult liver study St. Louis University Liver Biopsy Click Here for Locations M,F 0-18,18-35,35-65,65+ Liver ZZ Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone CSL Behring Alpha-1 proteinase inhibitor & Placebo Click Here for Locations M,F 18-35,35-65,65+ Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF Earco Registry. History of Patients with Alpha-1 Antitrypsin Hospital Universitari Vall d'Hebron Research Institute None Click Here for Locations M,F 0-18,18-35,35-65,65+ SZ,ZZ Evaluate Efficacy and Safety of "Kamada-AAT for inhalation" in Patients with AATD Kamada, Ltd. Placebos Click Here for Locations M,F 18-35,35-65 ZZ 
