Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype  |
Vertex Pharmaceuticals Incorporated |
VX-864 & Placebo |
Click Here for Locations |
|
18-35,35-65,65+ |
|
|
| Liver Disease in Patients with Alpha-1 Antitrypsin Deficiency |
RWTH Aachen University |
Observational |
Click Here for Locations |
M,F |
0-18,18-35,35-65,65+ |
Liver |
MS |
| Phase 1 study to assess the safety, PK and PD of INBRX-101 in adults with Alpha-1 (rhAAT-Fc) |
Inhibrx, Inc. |
INBRX-101/rhAAT-Fc |
Click Here for Locations |
M,F |
18-35,35-65,65+ |
|
MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Effects of different exercise training modalities in Alpha-1 Antitrypsin Deficiency |
Schön Klinik Berchtesgadener Land |
Observational |
Click Here for Locations |
M,F |
35-65,65+ |
|
ZZ |
| A Study of DCR-A1AT in Healthy Adult Volunteers and Patients With A1ATD-Associated Liver Disease |
Dicerna Pharmaceuticals, Inc. |
DCR-A1AT & placebo |
Click Here for Locations |
,M,F |
18-35,35-65,65+ |
Liver |
ZZ |
| Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency |
University of Alabama at Birmingham |
Alvelestat & Placebo |
Click Here for Locations
|
M,F |
18-35,35-65,65+ |
|
SZ,ZZ |
| Alpha-1 Research Registry |
Alpha-1 Foundation |
|
Click Here for Locations |
M,F |
0-18,18-35,35-65,65+ |
Liver,Lung |
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis |
Medical University of South Carolina |
|
Click Here for Locations |
,M,F |
18-35,35-65,65+ |
|
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| COPD Exacerbation Blood and Urine Biomarkers Study |
Columbia University Medical Center |
|
Click Here for Locations |
M,F |
35-65,65+ |
|
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs |
University of Florida |
Albuterol inhaler |
Click Here for Locations |
M,F |
18-35,35-65,65+ |
Lung |
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease |
McMaster University |
Hyperpolarized 129Xe & MRI |
Click Here for Locations |
M,F |
18-35,35-65,65+ |
Lung |
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Assessment of Changes in a Novel Histological Activity Scale in Response to ARO-AAT |
Arrowhead Pharmaceuticals |
ARO-AAT Injection |
Click Here for Locations |
M,F |
18-35,35-65,65+ |
|
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Safety, Tolerability and Effect on Liver Histologic Parameters of ARO-AAT |
Arrowhead Pharmaceuticals |
ARO-AAT Injection & Placebo |
Click Here for Locations |
M,F |
18-35,35-65,65+ |
Liver |
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. |
Mereo BioPharma |
Alvelestat oral tablet & Placebo |
Click Here for Locations |
M,F |
18-35,35-65,65+ |
|
Z,M,S,ZZ |
| Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype |
Vertex Pharmaceuticals Incorporated |
Vx-814 & Placebo |
Click Here for Locations |
M,F |
18-35,35-65,65+ |
|
ZZ |
| The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft‑Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant |
CSL Behring |
Alpha-1 Proteinase inhibitor & Placebo |
Click Here for Locations |
M,F |
|
|
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC) |
Arbor Research Collaborative for Health |
|
Click Here for Locations |
M,F |
0-18,18-35 |
Liver |
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD) |
Grifols Therapeutics LLC |
Prolastin-C & Placebo |
Click Here for Locations |
M,F |
18-35,35-65,65+ |
|
Z,S,SZ,ZZ |
| Alpha-1 Antitrypsin Deficiency Adult liver study |
St. Louis University |
Liver Biopsy |
Click Here for Locations |
M,F |
0-18,18-35,35-65,65+ |
Liver |
ZZ |
| Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone |
CSL Behring |
Alpha-1 proteinase inhibitor & Placebo |
Click Here for Locations |
M,F |
18-35,35-65,65+ |
|
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF |
| Earco Registry. History of Patients with Alpha-1 Antitrypsin |
Hospital Universitari Vall d'Hebron Research Institute |
None |
Click Here for Locations |
M,F |
0-18,18-35,35-65,65+ |
|
SZ,ZZ |
| Evaluate Efficacy and Safety of "Kamada-AAT for inhalation" in Patients with AATD |
Kamada, Ltd. |
Placebos |
Click Here for Locations |
M,F |
18-35,35-65 |
|
ZZ |
