Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype Vertex Pharmaceuticals Incorporated
VX-864 & Placebo
Click Here for Locations 18-35,35-65,65+
Liver Disease in Patients with Alpha-1 Antitrypsin Deficiency RWTH Aachen University
Observational
Click Here for Locations M,F
0-18,18-35,35-65,65+
Liver
MS
Phase 1 study to assess the safety, PK and PD of INBRX-101 in adults with Alpha-1 (rhAAT-Fc) Inhibrx, Inc.
INBRX-101/rhAAT-Fc
Click Here for Locations M,F
18-35,35-65,65+
MS,MZ,MF,SS,SZ,ZZ,FZ,FF
Effects of different exercise training modalities in Alpha-1 Antitrypsin Deficiency Schön Klinik Berchtesgadener Land
Observational
Click Here for Locations M,F
35-65,65+
ZZ
A Study of DCR-A1AT in Healthy Adult Volunteers and Patients With A1ATD-Associated Liver Disease Dicerna Pharmaceuticals, Inc.
DCR-A1AT & placebo
Click Here for Locations ,M,F
18-35,35-65,65+
Liver
ZZ
Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency University of Alabama at Birmingham
Alvelestat & Placebo
Click Here for Locations M,F
18-35,35-65,65+
SZ,ZZ
Alpha-1 Research Registry Alpha-1 Foundation
Click Here for Locations M,F
0-18,18-35,35-65,65+
Liver,Lung
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis Medical University of South Carolina
Click Here for Locations ,M,F
18-35,35-65,65+
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
COPD Exacerbation Blood and Urine Biomarkers Study Columbia University Medical Center
Click Here for Locations M,F
35-65,65+
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs University of Florida
Albuterol inhaler
Click Here for Locations M,F
18-35,35-65,65+
Lung
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease McMaster University
Hyperpolarized 129Xe & MRI
Click Here for Locations M,F
18-35,35-65,65+
Lung
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
Assessment of Changes in a Novel Histological Activity Scale in Response to ARO-AAT Arrowhead Pharmaceuticals
ARO-AAT Injection
Click Here for Locations M,F
18-35,35-65,65+
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
Safety, Tolerability and Effect on Liver Histologic Parameters of ARO-AAT Arrowhead Pharmaceuticals
ARO-AAT Injection & Placebo
Click Here for Locations M,F
18-35,35-65,65+
Liver
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. Mereo BioPharma
Alvelestat oral tablet & Placebo
Click Here for Locations M,F
18-35,35-65,65+
Z,M,S,ZZ
Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype Vertex Pharmaceuticals Incorporated
Vx-814 & Placebo
Click Here for Locations M,F
18-35,35-65,65+
ZZ
The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft‑Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant CSL Behring
Alpha-1 Proteinase inhibitor & Placebo
Click Here for Locations M,F
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC) Arbor Research Collaborative for Health
Click Here for Locations M,F
0-18,18-35
Liver
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD) Grifols Therapeutics LLC
Prolastin-C & Placebo
Click Here for Locations M,F
18-35,35-65,65+
Z,S,SZ,ZZ
Alpha-1 Antitrypsin Deficiency Adult liver study St. Louis University
Liver Biopsy
Click Here for Locations M,F
0-18,18-35,35-65,65+
Liver
ZZ
Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone CSL Behring
Alpha-1 proteinase inhibitor & Placebo
Click Here for Locations M,F
18-35,35-65,65+
Z,M,S,MS,MZ,MF,SS,SZ,ZZ,FZ,FF
Earco Registry. History of Patients with Alpha-1 Antitrypsin Hospital Universitari Vall d'Hebron Research Institute
None
Click Here for Locations M,F
0-18,18-35,35-65,65+
SZ,ZZ
Evaluate Efficacy and Safety of "Kamada-AAT for inhalation" in Patients with AATD Kamada, Ltd.
Placebos
Click Here for Locations M,F
18-35,35-65
ZZ
