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Welcome to the Alpha-1 Clinical Trial Search Engine

The Alpha-1 Foundation has developed an Alpha-1 Clinical Trial Search Engine with clinical trials that are specially curated with national and international Alpha-1 Antitrypsin Deficiency trials. You will be able to filter searches by gender, age group, condition, and genotype to be able to learn more about clinical trials. The Clinical Trial Search Engine was developed as an education tool to educate Alphas on what clinical trials are available for Alpha-1 Antitrypsin Deficiency and for Alphas to better understand the different types of research that are on-going.

Below are current studies that are specifically curated to Alpha-1 Antitrypsin Deficiency

Study Sponsor Interventions Location
Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype Vertex Pharmaceuticals Incorporated VX-864 & Placebo Click Here for Locations
Liver Disease in Patients with Alpha-1 Antitrypsin Deficiency RWTH Aachen University Observational Click Here for Locations
Phase 1 study to assess the safety, PK and PD of INBRX-101 in adults with Alpha-1 (rhAAT-Fc) Inhibrx, Inc. INBRX-101/rhAAT-Fc Click Here for Locations
Effects of different exercise training modalities in Alpha-1 Antitrypsin Deficiency Schön Klinik Berchtesgadener Land Observational Click Here for Locations
A Study of DCR-A1AT in Healthy Adult Volunteers and Patients With A1ATD-Associated Liver Disease Dicerna Pharmaceuticals, Inc. DCR-A1AT & placebo Click Here for Locations
Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency University of Alabama at Birmingham Alvelestat & Placebo Click Here for Locations

 
Alpha-1 Research Registry Alpha-1 Foundation Click Here for Locations
Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis Medical University of South Carolina Click Here for Locations
COPD Exacerbation Blood and Urine Biomarkers Study Columbia University Medical Center Click Here for Locations
Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs University of Florida Albuterol inhaler Click Here for Locations
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease McMaster University Hyperpolarized 129Xe & MRI Click Here for Locations
Assessment of Changes in a Novel Histological Activity Scale in Response to ARO-AAT Arrowhead Pharmaceuticals ARO-AAT Injection Click Here for Locations
Safety, Tolerability and Effect on Liver Histologic Parameters of ARO-AAT Arrowhead Pharmaceuticals ARO-AAT Injection & Placebo Click Here for Locations
A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. Mereo BioPharma Alvelestat oral tablet & Placebo Click Here for Locations
Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype Vertex Pharmaceuticals Incorporated Vx-814 & Placebo Click Here for Locations
The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft‑Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant CSL Behring Alpha-1 Proteinase inhibitor & Placebo Click Here for Locations
Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC) Arbor Research Collaborative for Health Click Here for Locations
Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD) Grifols Therapeutics LLC Prolastin-C & Placebo Click Here for Locations
Alpha-1 Antitrypsin Deficiency Adult liver study St. Louis University Liver Biopsy Click Here for Locations
Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone CSL Behring Alpha-1 proteinase inhibitor & Placebo Click Here for Locations
Earco Registry. History of Patients with Alpha-1 Antitrypsin Hospital Universitari Vall d'Hebron Research Institute None Click Here for Locations
Evaluate Efficacy and Safety of "Kamada-AAT for inhalation" in Patients with AATD Kamada, Ltd. Placebos Click Here for Locations
Study Sponsor Interventions Location

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