Last Month on Pubmed

This is a series of the latest published research on Alpha-1 Antitrypsin Deficiency. It is updated monthly, based on a search. Previous months’ listings are archived in the left sidebar of this page.

March 2019 Publications

Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice. Albarazanji K, Jennis M, Cavanaugh CR, Lang W, Singh B, Lanter JC, Lenhard JM, Hornby PJ. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 28. doi: 10.1152/ajpgi.00404.2018. [Epub ahead of print] PMID: 30920846 [PubMed - as supplied by publisher]

The Impact of Delayed Diagnosis of Alpha-1 Antitrypsin Deficiency: The Association Between Diagnostic Delay and Worsened Clinical Status. Tejwani V, Nowacki AS, Fye E, Sanders C, Stoller JK. Respir Care. 2019 Mar 26. pii: respcare.06555. doi: 10.4187/respcare.06555. [Epub ahead of print] PMID: 30914495 [PubMed - as supplied by publisher]

The alpha-1-antitrypsin promoter improves the efficacy of an AAV vector for the treatment of MNGIE. Cabrera-Pérez R, Vila-Julia F, Hirano M, Mingozzi F, Torres-Torronteras J, Marti R. Hum Gene Ther. 2019 Mar 22. doi: 10.1089/hum.2018.217. [Epub ahead of print] PMID: 30900470 [PubMed - as supplied by publisher]

Plant Serine Protease Inhibitors: Biotechnology Application in Agriculture and Molecular Farming. Clemente M, Corigliano MG, Pariani SA, Sánchez-López EF, Sander VA, Ramos-Duarte VA. Int J Mol Sci. 2019 Mar 17;20(6). pii: E1345. doi: 10.3390/ijms20061345. Review. PMID: 30884891 [PubMed - in process] Free Article

Analysis of a flagellar filament cap mutant reveals that HtrA serine protease degrades unfolded flagellin protein in the periplasm of Borrelia burgdorferi. Zhang K, Qin Z, Chang Y, Liu J, Malkowski MG, Shipa S, Li L, Qiu W, Zhang JR, Li C. Mol Microbiol. 2019 Mar 18. doi: 10.1111/mmi.14243. [Epub ahead of print] PMID: 30883947 [PubMed - as supplied by publisher]

Pulmonary Emphysema in a Child With Alpha-1 Antitrypsin Deficiency: Evaluation of 2 Years of Intravenous Augmentation Therapy. Esteves Brandão M, Conde B, Seixas S, Clotilde Silva J, Fernandes A. Arch Bronconeumol. 2019 Mar 11. pii: S0300-2896(19)30020-1. doi: 10.1016/j.arbres.2019.01.009. [Epub ahead of print] English, Spanish. No abstract available. PMID: 30871819 [PubMed - as supplied by publisher] Free Article

Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment. Ochiai N, Nakachi Y, Yokoo T, Ichihara T, Eriksson T, Yonemoto Y, Kato T, Ogata H, Fujimoto N, Kobayashi Y, Udagawa N, Kaku S, Ueki T, Okazaki Y, Takahashi N, Suda T. Commun Biol. 2019 Mar 1;2:86. doi: 10.1038/s42003-019-0334-5. eCollection 2019. PMID: 30854478 [PubMed] Free PMC Article \

Liver damage in a patient with Gaucher's disease type 1 and alpha-1 antitrypsin deficiency: a potential epigenetic effect? Alves Pedroso ML, Didoné Filho CN, Radunz V, de Barros JA. J Gastrointestin Liver Dis. 2019 Mar;28(1):121-123. doi: 10.15403/jgld.2014.1121.281.gau. PMID: 30851181 [PubMed - in process] Free Article

Quantum Mechanics/Molecular Mechanics (QM/MM) Calculations Support a Concerted Reaction Mechanism for the Zika Virus NS2B/NS3 Serine Protease with Its Substrate. Nutho B, Mulholland AJ, Rungrotmongkol T. J Phys Chem B. 2019 Apr 4;123(13):2889-2903. doi: 10.1021/acs.jpcb.9b02157. Epub 2019 Mar 15. PMID: 30845796 [PubMed - in process]

A Stress Buffering Perspective on the Progression of Alpha-1 Antitrypsin Deficiency. Tian X, Solomon DH, Smith RA.  Health Commun. 2019 Mar 7:1-9. doi: 10.1080/10410236.2019.1584782. [Epub ahead of print] PMID: 30843437 [PubMed - as supplied by publisher]

Modulation of calreticulin expression reveals a novel exosome mediated mechanism of Z variant alpha-1 antitrypsin disposal. Khodayari N, Oshins R, Alli AA, Tuna KM, Holliday LS, Krotova K, Brantly M. J Biol Chem. 2019 Mar 4. pii: jbc.RA118.006142. doi: 10.1074/jbc.RA118.006142. [Epub ahead of print] PMID: 30833329 [PubMed - as supplied by publisher] Free Article 

Limited GPA and Alpha-1 Antitrypsin Deficiency in a Pediatric Patient. Xie ES, Pai N, Batthish M. J Rheumatol. 2019 Mar 1. pii: jrheum.180979. doi: 10.3899/jrheum.180979. [Epub ahead of print] PMID: 30824654 [PubMed - as supplied by publisher]

Clinical impact of alpha-1-antitrypsin deficiency in ANCA-associated vasculitis: results from a French retrospective monocentric cohort of 142 consecutive patients. Deshayes S, Martin Silva N, Grandhomme F, Khoy K, Mariotte D, Boutemy J, Maigné G, Brière-Bellier C, Delmas C, Bienvenu B, Lobbedez T, de Boysson H, Aouba A. J Rheumatol. 2019 Mar 1. pii: jrheum.180591. doi: 10.3899/jrheum.180591. [Epub ahead of print] PMID: 30824651 [PubMed - as supplied by publisher]

How many protein molecules are secreted by single Helicobacter pylori cells: Quantification of serine protease HtrA. Neddermann M, Backert S. Cell Microbiol. 2019 Mar 1:e13022. doi: 10.1111/cmi.13022. [Epub ahead of print] PMID: 30822363 [PubMed - as supplied by publisher]

Sodium-site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study. Vadivel K, Schreuder HA, Liesum A, Schmidt AE, Goldsmith G, Bajaj SP. J Thromb Haemost. 2019 Apr;17(4):574-584. doi: 10.1111/jth.14401. Epub 2019 Mar 6. PMID: 30725510 [PubMed - in process]

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. Cohen I, Coban M, Shahar A, Sankaran B, Hockla A, Lacham S, Caulfield TR, Radisky ES, Papo N. J Biol Chem. 2019 Mar 29;294(13):5105-5120. doi: 10.1074/jbc.RA118.007292. Epub 2019 Jan 30. PMID: 30700553 [PubMed - in process]

Serine protease inhibitors rich Coccinia grandis (L.) Voigt leaf extract induces protective immune responses in murine visceral leishmaniasis. Pramanik A, Paik D, Pramanik PK, Chakraborti T. Biomed Pharmacother. 2019 Mar;111:224-235. doi: 10.1016/j.biopha.2018.12.053. Epub 2018 Dec 22. PMID: 30584985 [PubMed - in process] Free Article

Mitochondrial localization of St14-encoding transmembrane serine protease is involved in neural stem progenitor cell bioenergetics through binding to F<sub>0</sub>F<sub>1</sub>-ATP synthase complex. Fang JD, Tung HH, Lee SL. FASEB J. 2019 Mar;33(3):4327-4340. doi: 10.1096/fj.201801307R. Epub 2018 Dec 19. PMID: 30566397 [PubMed - in process]

The serine protease testisin is present on the surface of capacitated stallion spermatozoa and interacts with key zona pellucida binding proteins. Swegen A, Smith ND, Gibb Z, Curry BJ, Aitken RJ. Andrology. 2019 Mar;7(2):199-212. doi: 10.1111/andr.12569. Epub 2018 Dec 13. PMID: 30549223 [PubMed - in process]

Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles. Amann T, Hansen AH, Kol S, Hansen HG, Arnsdorf J, Nallapareddy S, Voldborg B, Lee GM, Andersen MR, Kildegaard HF. Metab Eng. 2019 Mar;52:143-152. doi: 10.1016/j.ymben 2018.11.014. Epub 2018 Dec 1. PMID: 30513349 [PubMed - in process]

Thymus-specific serine protease, a protease that shapes the CD4 T cell repertoire. Guerder S, Hassel C, Carrier A. Immunogenetics. 2019 Mar;71(3):223-232. doi: 10.1007/s00251-018-1078-y. Epub 2018 Sep 17. Review. PMID: 30225612 [PubMed - in process]

The effects of Enterolobium contortisiliquum serine protease inhibitor on the survival of the termite Nasutitermes corniger, and its use as affinity adsorbent to purify termite proteases. da Silva Ferreira R, Napoleão TH, Silva-Lucca RA, Silva MCC, Paiva PMG, Oliva MLV. Pest Manag Sci. 2019 Mar;75(3):632-638. doi: 10.1002/ps.5154. Epub 2018 Sep 17. PMID: 30051588 [PubMed - in process]Divider

This list of publications was generated on PubMed using the following Keywords:plus


    • alpha 1-Antitrypsin
    • alpha one antitrypsin
    • alpha 1 antitrypsine
    • alpha1-AT deficiency
    • alpha-1-AT
    • alpha 1 antiproteinase
    • alpha 1 antiprotease
    • alpha 1 protease
    • alpha 1 proteinase
    • familial emphysema
    • genetic emphysema
    • AATD
    • A1AT
    • hA1AT
    • A1-AT
    • A1P1
    • Prolastin
    • Aralast
    • Zemaira
    • Glassia