Last Month on Pubmed

This is a series of the latest published research on Alpha-1 Antitrypsin Deficiency. It is updated monthly, based on a search. Previous months’ listings are archived in the left sidebar of this page.

October 2017 Publications


Anti-apoptotic Serine Protease Inhibitors contribute towards the survival of allergenic Th2 cells.
Shamji MH, Temblay JN, Cheng W, Byrne SM, Macfarlane E, Switzer AR, Francisco NDC, Olexandra F, Jacubczik F, Durham SR, Ashton-Rickardt PG. 
J Allergy Clin Immunol. 2017 Oct 26; PMID: 229106998

Nafamostat mesilate, a serine protease inhibitor, suppresses interferon-gamma-induced up- regulation of programmed cell death ligand 1 in human cancer cells.
Homma S, Hayashi K, Yoshida K, Sagawa Y, Kamata Y, Ito M. 
Int Immunopharmacol. 2017 Oct 28;
PMID: 29100036

Cloning and characterization of a novel intracellular serine protease (IspK) from Bacillus megaterium with a potential additive for detergents.
Jeong YJ, Baek SC, Kim H. 
Int J Biol Macromol. 2017 Oct 31; PMID: 29097217

Toxoplasma gondii serine-protease inhibitor-1: A new adjuvant candidate for asthma therapy.
Soto AS, Fenoy IM, Sanchez VR, March F, Perrone Sibilia MD, Aldirico MLA, Picchio MS, Arcon N, Acosta PL, Polack FP, Martin V, Goldman A. 
PLoS One. 2017 Oct 26; PMID: 29073215

COPD in individuals with the PiMZ alpha-1 antitrypsin genotype.
Al Ashry HS, Strange C. 
Eur Respir Rev. 2017 Oct 25
PMID: 29070580

Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB.
Hassan T, de Santi C, Mooney C, McElvaney NG, Greene CM.
Sci Rep. 2017 Oct 23; PMID: 29062067

Thymic-Specific Serine Protease Limits Central Tolerance and Exacerbates Experimental Autoimmune Encephalomyelitis.

Serre L, Girard M, Ramadan A, Menut P, Rouquié N, Lucca LE, Mahiddine K, Leobon B, Mars LT, Guerder S. 
J Immunol. 2017 Oct 23. PMID: 29061767

The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloid.
Lanchec E, Désilets A, Béliveau F, Flamier A, Mahmoud S, Bernier G, Gris D, Leduc R, Lavoie C. 
J Biol Chem. 2017 Oct 20. 
PMID: 29054928

The prevalence of PI*S and PI*Z SERPINA1 alleles in healthy individuals and COPD patients in Saudi Arabia: A case-control study.
Al-Jameil N, Hassan AA, Hassanato R, Isac SR, Otaiby MA, Al-Shareef F, Al-Maarik B, Ajeyan IA, Al-Bahloul K, Ghani S, Al-Torbak D. 
Medicine (Baltimore). 2017 Oct; 
PMID: 29049242

Anti-inflammaging effects of human alpha-1 antitrypsin.

Yuan Y, DiCiaccio B, Li Y, Elshikha AS, Titov D, Brenner B, Seifer L, Pan H, Karic N, Akbar MA, Lu Y, Song S, Zhou L.
Aging Cell. 2017 Oct 17. 
PMID: 29045001

Characterization and mutation analysis of a halotolerant serine protease from a new isolate of Bacillus subtilis.
Takenaka S, Yoshinami J, Kuntiya A, Techapun C, Leksawasdi N, Seesuriyachan P, Chaiyaso T, Watanabe M, Tanaka K, Yoshida KI. Biotechnol Lett. 2017 Oct 16. PMID: 29038928

Massive ascites and the heterozygous alpha 1 antitrypsin (α1 AT) living related donor liver in the homozygous child.
Khorsandi SE, Thompson R, Vilca-Melendez H, Dhawan A, Heaton N.
Pediatr Transplant. 2017 Oct 15. 
PMID: 29034613 

A1AT polymorphisms may be associated with clinical characteristics of retrovirus infections in a mixed ethnic population from the Brazilian Amazon region.
Ferreira TCDS, Queiroz MAF, Argañaraz GA, Ishak R, Vallinoto ACR, Argañaraz ER.
Int J Infect Dis. 2017 Oct 10; PMID: 29030134

Total proteolytic activity and concentration of alpha-1 antitrypsin in meconium for assessment of the protease/antiprotease balance.

Skarżyńska E, Kiersztyn B, Wilczyńska P, Jakimiuk A, Lisowska-Myjak B. 
Eur J Obstet Gynecol Reprod Biol. 2017 Oct 4. PMID: 29029865 

Involvement of the Arg566 residue of Aeromonas sobria serine protease in substrate specificity.
Kobayashi H, Otsubo T, Teraoka F, Ikeda K, Seike S, Takahashi E, Okamoto K, Yoshida T, Tsuge H, Yamanaka H. 
PLoS One. 2017 Oct 12;
 PMID: 29023605

Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2.
Merski M, Moreira C, Abreu RM, Ramos MJ, Fernandes PA, Martins LM, Pereira PJB, 
Macedo-Ribeiro S.
Cell Death Dis. 2017 Oct 12; PMID: 29022916

Bioequivalence of a Liquid Formulation of Alpha1-Proteinase Inhibitor Compared with Prolastin®-C (Lyophilized Alpha1-PI) in Alpha1- Antitrypsin Deficiency.
Barker AF, Campos MA, Brantly ML, Stocks JM, Sandhaus RA, Lee D, Steinmann K, Lin J, Sorrells S. COPD. 2017 Oct 6; PMID: 28985109

Identification of a new defective SERPINA1 allele (PI*Zla palma) encoding an alpha-1-antitrypsin with altered glycosylation pattern. 

Hernández-Pérez JM, Ramos-Díaz R, Pérez JA.
Respir Med. 2017 Oct; 
PMID: 28947017

The important role of primary care providers in the detection of alpha-1 antitrypsin deficiency.
Lascano JE, Campos MA.
Postgrad Med. 2017 Oct 5: 
PMID: 28929906 

Anti-fibrinolytic and anti-microbial activities of a serine protease inhibitor from honeybee (Apis cerana) venom.
Yang J, Lee KS, Kim BY, Choi YS, Yoon HJ, Jia J, Jin BR. 
Comp Biochem Physiol C Toxicol Pharmacol. 2017 Oct;
PMID: 28917645

Oncostatin M and TNF-α Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells.
Ni K, Umair Mukhtar Mian M, Meador C, Gill A, Barwinska D, Cao D, Justice MJ, Jiang D, Schaefer N, Schweitzer KS, Chu HW, March KL, Petrache I. 
Stem Cells Dev. 2017 Oct 15;
PMID: 28825379 

The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cells.
Hsieh HH, Chen YC, Jhan JR, Lin JJ.
J Cell Sci. 2017 Oct 1;
PMID: 28794016

Alpha 1 Antitrypsin Deficiency.

Meseeha M, Attia M.
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2017 Jun-. PMID: 28723059

Alpha-1-antitrypsin for the treatment of steroid-refractory acute gastrointestinal graft-versus- host disease.
Jerkins JH, Hamadani M, Zook F, Epperla N, Shaw BE, Saber W, Rizzo JD, Pasquini M, Chhabra S, Drobyski WR, Hari PN, Shah NN. 
Am J Hematol. 2017 Oct;
 PMID: 28699171

Ac2-26 peptide and serine protease of Bothrops atrox similarly induces angiogenesis without triggering local and systemic inflammation in a murine model of dorsal skinfold chamber.
Molás RB, de Paula-Silva M, Masood R, Ullah A, Gimenes AD, Oliani SM. 
Toxicon. 2017 Oct;
 PMID: 28676453

A clip domain serine protease involved in moulting in the silkworm, Bombyx mori: cloning, characterization, expression patterns and functional analysis.
Liu HW, Wang LL, Meng Z, Tang X, Li YS, Xia QY, Zhao P.
Insect Mol Biol. 2017 Oct; PMID: 28597953

Erdj3 Has an Essential Role for Z Variant Alpha-1-Antitrypsin Degradation.

Khodayari N, Marek G, Lu Y, Krotova K, Wang RL, Brantly M.
J Cell Biochem. 2017 Oct; PMID: 28419579

A midgut-specific serine protease, BmSP36, is involved in dietary protein digestion in the silkworm, Bombyx mori
Liu HW, Li YS, Tang X, Guo PC, Wang DD, Zhou CY, Xia QY, Zhao P. 
Insect Sci. 2017 Oct; PMID: 27311916




This list of publications was generated on PubMed using the following Keywords:plus


    • alpha 1-Antitrypsin
    • alpha one antitrypsin
    • alpha 1 antitrypsine
    • alpha1-AT deficiency
    • alpha-1-AT
    • alpha 1 antiproteinase
    • alpha 1 antiprotease
    • alpha 1 protease
    • alpha 1 proteinase
    • familial emphysema
    • genetic emphysema
    • AATD
    • A1AT
    • hA1AT
    • A1-AT
    • A1P1
    • Prolastin
    • Aralast
    • Zemaira
    • Glassia​