Since
Alpha-1
Antitrypsin
Deficiency
is
an
inherited
disorder,
it
occurs
when
both
parents
pass
on a
abnormal
gene
to
their
child.
A
father
and
mother
who
are
both
carriers
(MZ)
could
expect
to
have
a
50%
chance
of
having
a
carrier,
and
a
25%
chance
of
having
either
a
healthy
or a
deficient
child.
If
one
parent
has
the
ZZ
genotype,
and
the
other
has
two
normal
copies
of
the
gene
(MM),
their
children
will
be
carriers
for
Alpha-1.
